Most photo frames, poster frames, certificate frames and picture frames consist of a wooden frame and a pane of glass. The picture frame moulding (frame) is often finely finished with gold or silver foils or leaves being a few micron ( very thin) thick. Many household cleaners contain ammonia, solvents and abrasives and shouldn't be used to clean frames lest the finish .. or colour of the frame come off accidentally. Perhaps the best way to keep a picture frame clean is to gently dust it regularly to prevent the dust and dirt ...